The flight distance from Denver International Airport (DEN) in Denver, United States to Cerro Largo International Airport (MLZ) in Melo, Uruguay is 9,560 kilometers (5,941 miles / 5,162 nautical miles). The estimated flight time for this route is approximately 12h, flying southeast at a heading of 139°.

This is an ultra-long-haul route, one of the longest in aviation. It requires wide-body aircraft with extended range capability such as the Airbus A350-900ULR or Boeing 777-200LR. Passengers should prepare for an extended flight with multiple meal services.

This is an international route connecting United States with Uruguay. It is an intercontinental flight between North America and South America. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 22:44 in Denver, it's 02:44 in Melo. The 4-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

There is a significant elevation difference of 5,070 feet between the two airports. Cerro Largo International Airport sits lower than Denver International Airport. Travelers arriving at the higher-elevation airport should be aware of potential altitude effects.

The return flight from Melo (MLZ) to Denver (DEN) follows a heading of 324° (northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Denver International Airport (DEN) and Cerro Largo International Airport (MLZ) detail pages, or use our flight duration calculator to compare other routes.