The flight distance from Daniel K Inouye International Airport (HNL) in Honolulu, United States to Cerro Largo International Airport (MLZ) in Melo, Uruguay is 12,497 kilometers (7,765 miles / 6,748 nautical miles). The estimated flight time for this route is approximately 16h, flying east southeast at a heading of 117°.

This is an ultra-long-haul route, one of the longest in aviation. It requires wide-body aircraft with extended range capability such as the Airbus A350-900ULR or Boeing 777-200LR. Passengers should prepare for an extended flight with multiple meal services.

This is an international route connecting United States with Uruguay. It is an intercontinental flight between North America and South America. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 21:23 in Honolulu, it's 04:23 in Melo. With a 7-hour time difference, travelers should plan for significant jet lag. It typically takes one day per hour of time difference to fully adjust.

The return flight from Melo (MLZ) to Honolulu (HNL) follows a heading of 282° (west northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Daniel K Inouye International Airport (HNL) and Cerro Largo International Airport (MLZ) detail pages, or use our flight duration calculator to compare other routes.