The flight distance from Jose Maria Cordova International Airport (MDE) in Rionegro, Colombia to Ruben Cantu Airport (SYP) in Santiago, Panama is 647 kilometers (402 miles / 349 nautical miles). The estimated flight time for this route is approximately 2h, flying west northwest at a heading of 290°.

This is a short-haul route typically served by narrow-body aircraft such as the Boeing 737 or Airbus A320 family. In-flight service is usually limited to drinks and light snacks.

This is an international route connecting Colombia with Panama. It is an intercontinental flight between South America and North America. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 05:56 in Rionegro, it's 05:56 in Santiago.

There is a significant elevation difference of 6,683 feet between the two airports. Ruben Cantu Airport sits lower than Jose Maria Cordova International Airport. Travelers arriving at the higher-elevation airport should be aware of potential altitude effects.

The return flight from Santiago (SYP) to Rionegro (MDE) follows a heading of 109° (east southeast). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Jose Maria Cordova International Airport (MDE) and Ruben Cantu Airport (SYP) detail pages, or use our flight duration calculator to compare other routes.