The flight distance from Cerro Largo International Airport (MLZ) in Melo, Uruguay to San Francisco International Airport (SFO) in San Francisco, United States is 10,502 kilometers (6,526 miles / 5,671 nautical miles). The estimated flight time for this route is approximately 13h, flying northwest at a heading of 312°.

This is an ultra-long-haul route, one of the longest in aviation. It requires wide-body aircraft with extended range capability such as the Airbus A350-900ULR or Boeing 777-200LR. Passengers should prepare for an extended flight with multiple meal services.

This is an international route connecting Uruguay with United States. It is an intercontinental flight between South America and North America. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 18:36 in Melo, it's 14:36 in San Francisco. The 4-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

The return flight from San Francisco (SFO) to Melo (MLZ) follows a heading of 128° (southeast). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the Cerro Largo International Airport (MLZ) and San Francisco International Airport (SFO) detail pages, or use our flight duration calculator to compare other routes.