The flight distance from San Francisco International Airport (SFO) in San Francisco, United States to Sancti Spiritus Airport (USS) in Sancti Spiritus, Cuba is 4,447 kilometers (2,763 miles / 2,401 nautical miles). The estimated flight time for this route is approximately 6h, flying east at a heading of 101°.

This is a long-haul route typically operated by wide-body aircraft such as the Boeing 777 or Airbus A350. Full meal service, in-flight entertainment, and comfort amenities are standard.

This is an international route connecting United States with Cuba. Travelers should check visa requirements, customs regulations, and any travel advisories before booking.

Time zone information: When it's 00:04 in San Francisco, it's 03:04 in Sancti Spiritus. The 3-hour time difference may cause some jet lag. Most travelers adjust within a day or two.

The return flight from Sancti Spiritus (USS) to San Francisco (SFO) follows a heading of 303° (west northwest). Actual flight times may vary depending on wind conditions, air traffic, and the specific aircraft used.

For more information about these airports, visit the San Francisco International Airport (SFO) and Sancti Spiritus Airport (USS) detail pages, or use our flight duration calculator to compare other routes.